Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with α-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.

中文翻译：

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与副肿瘤性自身免疫性视网膜病相关的主要抗视网膜自身抗体的发生。

在患有癌症且与癌症转移无关的原因不明的视力丧失的患者中，可以发现针对视网膜抗原的自身抗体（AAb）。癌症相关性视网膜病（CAR）是一种由Abb介导的罕见的副肿瘤性视觉综合征。我们的目标是确定具有不同恶性肿瘤的CAR患者是否具有可作为视网膜疾病生物标志物的特定Abb或AAb的全部组成。我们发现针对12种已确认的视网膜抗原的Abs，其中最常见的是α-烯醇酶。该研究的重要发现是结肠癌中抗醛缩酶AAb的发生率高，前列腺癌CAR中抗CAII的发生率高，皮肤黑素瘤患者中的抗抑制素的发生率高，因此这些Aab可以在临床表现和临床表现中用作生物标志物。可以支持CAR的诊断。然而，