OBJECTIVE To investigate acute kidney injury (AKI) in neonates with a patent ductus arteriosus (PDA) including incidence, risk factors, and possible correlations between PDA-related echocardiographic measurements and AKI incidence. STUDY DESIGN We conducted a single-center retrospective cohort study of infants admitted to the neonatal intensive care unit with a diagnosis of a PDA between July 2015 and July 2017. Infants were evaluated for development of AKI based on the KDIGO criteria and a multivariable logistic regression analysis was performed. RESULTS A total of 142 neonates with moderate or large PDAs were included, 43 (30%) developed AKI. Patients who developed AKI had longer length of stay, lower birth weights, lengths, and gestational ages. No echocardiographic measurements were predictive of an increased risk for developing AKI. CONCLUSION There are no significant differences in commonly measured echocardiographic markers of PDA hemodynamic significance in neonates who develop AKI.

中文翻译：

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超声心动图预测动脉导管未闭的新生儿急性肾损伤。

目的探讨新生儿动脉导管未闭（PDA）的急性肾损伤（AKI），包括发生率，危险因素以及与PDA相关的超声心动图测量与AKI发生率之间的可能相关性。研究设计我们对2015年7月至2017年7月间诊断为PDA的新生儿重症监护病房的婴儿进行了单中心回顾性队列研究。根据KDIGO标准和多因素logistic回归对婴儿的AKI进行评估。进行了分析。结果纳入了142例具有中度或大型PDA的新生儿，其中43例（30％）发展为AKI。发生AKI的患者住院时间更长，出生体重，身长和胎龄较低。没有超声心动图测量可预测发生AKI的风险增加。