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Reprogramming of cellular metabolic pathways by human oncogenic viruses.
Current Opinion in Virology ( IF 5.9 ) Pub Date : 2019-11-22 , DOI: 10.1016/j.coviro.2019.11.002
John G Purdy 1 , Micah A Luftig 2
Affiliation  

Oncogenic viruses, like all viruses, relies on host metabolism to provide the metabolites and energy needed for virus replication. Many DNA tumor viruses and retroviruses will reprogram metabolism during infection. Additionally, some viral oncogenes may alter metabolism independent of virus replication. Virus infection and cancer development share many similarities regarding metabolic reprogramming as both processes demand increased metabolic activity to produce biomass: cell proliferation in the case of cancer and virion production in the case of infection. This review discusses the parallels in metabolic reprogramming between human oncogenic viruses and oncogenesis.



中文翻译:

人类致癌病毒对细胞代谢途径的重新编程。

像所有病毒一样,致癌病毒也依赖宿主代谢来提供病毒复制所需的代谢物和能量。许多DNA肿瘤病毒和逆转录病毒会在感染过程中重新编程新陈代谢。此外,某些病毒致癌基因可能会独立于病毒复制而改变新陈代谢。病毒感染和癌症发展在代谢重编程方面有许多相似之处,因为这两个过程都需要增加代谢活性才能产生生物质:癌症时细胞增殖,感染时病毒体产生。这篇评论讨论了人类致癌病毒和致癌之间代谢重编程的相似之处。

更新日期:2019-11-22
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