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Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2019-11-25 , DOI: 10.1021/acs.jnatprod.9b00675
Ma Yadanar Phyo 1, 2 , Chi Ying Gary Ding 1 , Hui Chin Goh 3 , Jun Xian Goh 1 , Ji Fa Marshall Ong 1 , Siew Herng Chan 4 , Pui Yi Maria Yung 4 , Hartono Candra 2 , Lik Tong Tan 1
Affiliation  

A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.

中文翻译:

Trikoramide A,来自海洋蓝藻Syploca hydnoides的异戊烯化蓝细菌素。

从印度尼西亚民丹岛收集的海洋蓝藻Symploca hydnoides样品中分离出一种新的环十肽三肽酰胺A(1)。Trikoramide A(1)是一种C-烯丙基化的含环色氨酸的氰基actin。通过1D和2D NMR光谱以及HR-MS / MS数据推导了其平面结构。此外,其绝对构型是通过Marfey方法和2D NOESY NMR光谱分析确定的。化合物1具有针对MOLT-4和AML2癌细胞系的细胞毒性,IC50值分别为4.8和8.2μM。
更新日期:2019-11-28
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