Magnetic particle hyperthermia is a promising cancer therapy, but a typical constraint of its applicability is localizing heat solely to malignant regions sparing healthy surrounding tissues. By simultaneous application of a constant magnetic field together with the hyperthermia inducing alternating magnetic field, heating focus may be confined to smaller regions in a tunable manner. The main objective of this work is to evaluate the focusing parameters, by adequate selection of magnetic nanoparticles and field conditions, and explore spatially focused magnetic particle hyperthermia efficiency in tissue phantom systems comprising agarose gel and magnetic nanoparticles. Our results suggest the possibility of spatially focused heating efficiency of magnetic nanoparticles through the application of a constant magnetic field. Tuning of the constant magnetic field parameters may result in minimizing thermal shock in surrounding regions without affecting the beneficiary thermal outcome in the focusing region.

中文翻译：

---

磁粉热疗的空间聚焦

磁粒子热疗是一种很有前途的癌症疗法，但其适用性的一个典型限制是将热量仅定位于恶性区域，而不会影响健康的周围组织。通过同时施加恒定磁场和高热感应交变磁场，可以以可调的方式将加热焦点限制在较小的区域。这项工作的主要目的是通过充分选择磁性纳米粒子和场条件来评估聚焦参数，并探索包含琼脂糖凝胶和磁性纳米粒子的组织模型系统中的空间聚焦磁性粒子热疗效率。我们的研究结果表明，通过施加恒定磁场可以实现磁性纳米粒子的空间聚焦加热效率。