In rodents, the anterior cingulate (ACC), prelimbic (PL), and infralimbic cortex (IL) comprise the medial prefrontal cortex (mPFC). Through extensive connections with cortical and subcortical structures, the mPFC plays a key modulatory role in the neuronal circuits underlying associative fear and reward learning. In this article, we have compiled the evidence that associative learning induces plasticity in both the intrinsic and synaptic excitability of mPFC neurons to modulate conditioned fear and cocaine seeking behavior. The literature highlights the accumulating evidence that plasticity in the intrinsic excitability of mPFC neurons represents a major cellular mechanism that interacts with synaptic changes to alter the impact of the mPFC on fear and reward circuits.

中文翻译：

---

啮齿动物内侧前额叶皮层中学习诱导的内在和突触可塑性。

在啮齿动物中，前扣带回（ACC），前缘（PL）和下缘皮质（IL）构成内侧前额叶皮质（mPFC）。通过与皮质和皮质下结构的广泛连接，mPFC在潜在的联想恐惧和奖励学习的神经元回路中起着关键的调节作用。在本文中，我们收集了以下证据：联想学习在mPFC神经元的内在和突触兴奋性中诱导可塑性，以调节条件性恐惧和可卡因寻求行为。文献突出了越来越多的证据表明，mPFC神经元固有兴奋性的可塑性代表了一种主要的细胞机制，该机制与突触变化相互作用，以改变mPFC对恐惧和奖赏回路的影响。