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Parametric Characterization of a Taste Phenotype in Rats Selectively Bred for High Versus Low Saccharin Intake.
Chemical Senses ( IF 3.5 ) Pub Date : 2019-11-23 , DOI: 10.1093/chemse/bjz072
Nancy K Dess 1 , Clinton D Chapman 1
Affiliation  

Taste signals food quality and reflects energy status and associated processes. Occidental high- and low-saccharin consuming rats (HiS, LoS) have been selectively bred for nearly 60 generations on intake of 0.1% saccharin in a 23-h two-bottle test, as a tool for studying individual differences in taste and its correlates in the domains of feeding, defensive, and social behavior. The saccharin phenotype itself has not been well characterized until now. The present series of parametric studies examined suprathreshold saccharin concentration-intake functions (Experiment 1), saccharin preference threshold (Experiments 2A and 2B), and intra- and inter-sweetener carryforward effects (Experiments 2B, 3A–3D). Results indicate high stability in line differences in behavior toward saccharin and also line-specific mutability of intake of saccharin and certain other sweeteners. Methodological and conceptual implications are discussed.

中文翻译:

高品位和低糖精摄入量选择性繁殖的大鼠口味表型的参数化表征。

口味表示食品质量,并反映能量状态和相关过程。在23小时的两瓶试验中,西方食用高糖精和低糖精的大鼠(HiS,LoS)在摄入0.1%糖精的情况下被选择性饲养了近60代,是研究个体口味差异及其相关性的工具在喂养,防御和社会行为方面。到目前为止,糖精表型本身还没有很好的表征。本系列参数研究研究了糖精的超临界摄入量功能(实验1),糖精偏好阈值(实验2A和2B)以及甜味剂内部和甜味剂之间的结转效应(实验2B,3A-3D)。结果表明,对于糖精的行为差异具有高度的稳定性,并且糖精和某些其他甜味剂的摄入具有特定的线路变异性。讨论了方法论和概念上的含义。
更新日期:2020-04-17
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