Activity-based protein profiling (ABPP) and bioimaging have been developed in recent years as powerful technologies in drug discovery. Specifically, both approaches can be applied in critical steps of drug development, such as therapy target discovery, high-throughput drug screening and target identification of bioactive molecules. We have been focused on the development of various strategies that enable simultaneous activity-based protein profiling and bioimaging studies, thus facilitating an understanding of drug actions and potential toxicities. In this Minireview, we summarize these novel strategies and applications, with the aim of promoting these technologies in drug discovery.

中文翻译：

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基于活动的蛋白质谱分析（ABPP）和生物成像在药物发现中的应用。

近年来，基于活动的蛋白质谱分析（ABPP）和生物成像技术已成为药物发现中的强大技术。具体而言，这两种方法均可用于药物开发的关键步骤，例如治疗靶标发现，高通量药物筛选和生物活性分子的靶标鉴定。我们一直致力于各种策略的开发，这些策略可以同时进行基于活动的蛋白质谱分析和生物成像研究，从而促进对药物作用和潜在毒性的了解。在此Minireview中，我们总结了这些新颖的策略和应用，旨在在药物发现中促进这些技术。