We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis. The topology of ubonodin is unprecedented amongst lasso peptides, with 18 of its 28 amino acids found in the mechanically bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans, causative agents of lung infections in cystic fibrosis patients.

中文翻译：

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Ubonodin的发现，一种抗菌的套索肽，对伯克霍尔德菌洋葱的构成很有效。

我们报告了在伯克霍尔德菌ubonensis基因组中编码的套索肽，ubonodin的异源表达，结构和抗菌活性。在套索肽中，ubonodin的拓扑结构是前所未有的，其28个氨基酸中的18个位于机械结合的环段中。Ubonodin在体外抑制RNA聚合酶，对Burkholderia属的几个病原体具有有效的抗菌活性，最显着的是B. cepacia和B. multivorans，它们是囊性纤维化患者肺部感染的病原体。