To assess associations of intoxication frequency and number of drinks needed to become intoxicated in mid-adolescence with onset of psychiatric disorders in early adulthood. Prospective cohort study. Northern Finland. People from the Northern Finland Birth Cohort 1986 who self-reported adolescent alcohol use: 6,548 subjects (69.4% of the original sample). Data on alcohol use were collected using questionnaires at ages 15 - 16 years. Outcomes were any non-organic psychosis, mood disorder, anxiety disorder, any substance use disorder (SUD) and all the studied psychiatric disorders in early adulthood gathered from nationwide health care, pension and insurance registers. Number of drinks needed to become intoxicated was categorized into three classes: (1) No alcohol use or intoxication, and (2) low and (3) high alcohol tolerance (more than 7/9 drinks for females/males) groups. Similarly, intoxication frequency was divided into three classes: (1) never, (2) 1 - 2 times and (3) 3 or more times during the past 30 days. Information regarding gender, family type, other drug use, psychopathology using Youth Self-Report (YSR) total score, and parental psychiatric disorders were used as covariates. In the multivariable analyses, both low [OR 3.0, 95% CI 1.3 - 6.7, p-value=0.009] and high [OR 4.4, 95% CI 1.8 - 11.1, p-value=0.001] alcohol tolerance were associated with increased risk of SUD. More frequent intoxication was associated with increased frequency of SUD [OR 3.9, 95% CI 2.0 - 7.3, p-value<0.001] and mood disorder [OR 1.6, 95% CI 1.1 - 2.3, p-value=0.008]. The latter was attenuated after adjusting with concurrent psychopathology (YSR) and other drug use. Both higher alcohol tolerance and frequent intoxication in adolescence appear to be associated with increased risk of future substance use disorder.

中文翻译：

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青春期频繁中毒和酒精耐受性：与青年期精神疾病的关联

评估在青春期中期醉酒所需的醉酒频率和饮酒数量与成年早期精神疾病发作之间的关联。前瞻性队列研究。芬兰北部。来自芬兰北部出生队列的 1986 年自我报告青少年饮酒的人：6,548 名受试者（原始样本的 69.4%）。使用问卷收集了 15-16 岁的饮酒数据。结果是任何非器质性精神病、情绪障碍、焦虑症、任何物质使用障碍 (SUD) 以及从全国医疗保健、养老金和保险登记册收集的所有研究的成年早期精神障碍。醉酒所需的饮料数量分为三类：（1）不使用酒精或醉酒，(2) 低和 (3) 高酒精耐受性（女性/男性饮酒量超过 7/9）组。类似地，中毒频率分为三类：（1）从不，（2）1-2 次和（3）过去 30 天内 3 次或更多次。有关性别、家庭类型、其他药物使用、使用青年自我报告 (YSR) 总分的精神病理学和父母精神疾病的信息被用作协变量。在多变量分析中，低 [OR 3.0, 95% CI 1.3 - 6.7, p-value=0.009] 和高 [OR 4.4, 95% CI 1.8 - 11.1, p-value=0.001] 酒精耐受性与风险增加有关SUD 的。更频繁的中毒与 SUD [OR 3.9, 95% CI 2.0 - 7.3, p-value <0.001] 和情绪障碍 [OR 1.6, 95% CI 1.1 - 2.3, p-value=0.008] 频率增加有关。后者在同时进行精神病理学 (YSR) 和其他药物使用调整后减弱。青春期较高的酒精耐受性和频繁中毒似乎与未来物质使用障碍的风险增加有关。