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Standard mortality rates and years of life lost for serologically defined adult-onset type 1 and type 2 diabetes - A fifteen year follow-up.
Diabetes Research and Clinical Practice ( IF 5.1 ) Pub Date : 2019-11-22 , DOI: 10.1016/j.diabres.2019.107943
Maria Thunander 1 , Anna Lindgren 2 , Christer Petersson 3 , Mona Landin-Olsson 4 , Sara Holmberg 5
Affiliation  

AIMS The Diabetes Incidence in Kronoberg (DIK) study of adult-onset diabetes used serological classification. Standard Mortality Rates (SMR) and Years of Life Lost (YLL) 15 years after adult-onset (18-100 years) of diabetes were compared to the population of Kronoberg. METHODS Of 1609/1660 (97%) patients, 112 (7%) had type 1 (T1D) (GADA+ and/or ICA+, and/or C-peptide < 0.25 nmol/l), and 1497 (93%) had type 2 diabetes (T2D) (antibody- and C-peptide ≥ 0.25 nmol/l). The National Swedish Mortality Register provided time of death. RESULTS For T1D SMR did not differ from the Kronoberg population in any age group. In T2D SMR was 1.20 (1.12-1.29). After 15 years 26% (29/112) T1D and 52% (785/1497) T2D patients had died, p < 0.0001. In T2D SMR was 5.6 (30-39 years), 2 (40-59 years), 1.4 (60-69 years), and thereafter no difference. There were no significant sex differences in mortality, and no YLL to adult-onset T1D, but five YLL to T2D for onset at ages 20-60 years. CONCLUSIONS For adult-onset T1D SMR did not differ from the general population, in contrast to previous findings in childhood-onset (< 30 years of age) T1D. The difference in mortality between persons with diabetes and the general population was due to higher mortality in T2D.

中文翻译:

血清学确定的成人发作的1型和2型糖尿病的标准死亡率和丧失的生命年-进行了15年的随访。

目的采用血清学分类法对成年糖尿病的克罗诺贝格糖尿病发病率(DIK)研究。将成人成年糖尿病(18-100年)后15年的标准死亡率(SMR)和生命损失年限(YLL)与克罗诺贝格(Kronoberg)人群进行了比较。方法在1609/1660(97%)的患者中,有112(7%)患有1型(T1D)(GADA +和/或ICA +,和/或C肽<0.25 nmol / l),而1497(93%)患有1型(T1D) 2糖尿病(T2D)(抗体和C肽≥0.25 nmol / l)。瑞典国家死亡率登记处提供了死亡时间。结果在任何年龄段,T1D SMR与克罗诺贝格人群均无差异。在T2D中,SMR为1.20(1.12-1.29)。15年后,有26%(29/112)T1D和52%(785/1497)T2D患者死亡,p <0.0001。在T2D中,SMR为5.6(30-39岁),2(40-59岁),1.4(60-69岁),此后没有差异。死亡率没有明显的性别差异,成年发病的T1D没有YLL,但是20-60岁发病的发病有5个YLL到T2D。结论对于成人发病的T1D,SMR与一般人群没有区别,与先前在儿童期发病(<30岁)的T1D的发现相反。糖尿病患者和普通人群之间的死亡率差异是由于T2D死亡率较高所致。
更新日期:2019-11-22
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