In the double-blind STARTS clinic trial (n=100), Valiengo and colleagues compared frontotemporoparietal transcranial direct current stimulation (tDCS; 20 minutes twice daily for 5 days) with sham treatment as an add-on treatment for negative symptoms in schizophrenia. At 6 weeks, the decrease from baseline in the Positive and Negative Syndrome Scale negative symptoms subscale score was greater in the active treatment group than the sham treatment group (−4·49 [SD 3·50] vs −1·84 [1·82]; group difference 2·65 [95% CI 1·51–3·79]; p<0·001), with the difference maintained at 12 weeks follow-up (2·35 [1·02–3·67]; p<0·001). Apart from burning sensation at day 5 with tDCS, the frequency of adverse events was similar between the two groups, and no serious adverse events were noted.

中文翻译：

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研究综述。

在双盲STARTS临床试验（n = 100）中，Valiengo及其同事比较了额颞颞顶经颅直流电刺激（tDCS；每天20分钟，每天两次，共5天）作为精神分裂症阴性症状的附加治疗。在第6周时，积极治疗组的阳性和阴性症状量表阴性症状分量表评分从基线开始的降低幅度大于假治疗组（−4·49 [SD 3·50] vs -1·84 [1· 82]；小组差异2·65 [95％CI 1·51-3·79]； p <0·001），差异在随访12周时维持（2·35 [1·02-3·67] ]； p <0·001）。除了第5天使用tDCS的灼热感外，两组之间的不良事件发生频率相似，并且未发现严重的不良事件。