Significant evidence demonstrates that aging is associated with variability in cognitive performance, even among individuals who are cognitively normal. In this study, we examined measures from magnetic resonance imaging and cerebrospinal fluid (CSF) to investigate which measures, alone or in combination, were associated with individual differences in episodic memory performance. Using hierarchical linear regressions, we compared the ability of diffusion tensor imaging (DTI) metrics, CSF measures of amyloid and tau, and gray matter volumes to explain variability in memory performance in a cohort of cognitively normal older adults. Measures of DTI microstructure were significantly associated with variance in memory performance, even after accounting for the contribution of the CSF and magnetic resonance imaging gray matter volume measures. Significant associations were found between DTI measures of the hippocampal cingulum and fornix with individual differences in memory. No such relationships were found between memory performance and CSF markers or gray matter volumes. These findings suggest that DTI metrics may be useful in identifying changes associated with aging or age-related diseases.

中文翻译：

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内侧颞叶白质通路变异与认知正常老年人情景记忆的个体差异相关

大量证据表明，衰老与认知表现的变异性有关，即使对于认知能力正常的个体也是如此。在这项研究中，我们检查了磁共振成像和脑脊液 (CSF) 的测量值，以研究哪些测量值单独或组合与情景记忆表现的个体差异相关。使用分层线性回归，我们比较了扩散张量成像 (DTI) 指标、脑脊液淀粉样蛋白和 tau 蛋白测量以及灰质体积的能力，以解释一组认知正常的老年人的记忆表现变异性。即使考虑了脑脊液和磁共振成像灰质体积测量的贡献，DTI 微观结构的测量与记忆性能的差异显着相关。研究发现海马扣带回和穹窿的 DTI 测量值与个体记忆差异存在显着相关性。在记忆表现和脑脊液标记或灰质体积之间没有发现这种关系。这些发现表明 DTI 指标可能有助于识别与衰老或年龄相关疾病相关的变化。