Objective Evaluate a physiotherapist-led telephone-delivered exercise advice and support intervention for people with knee osteoarthritis. Methods Participant-blinded, assessor-blinded randomised controlled trial. 175 people were randomly allocated to (1) existing telephone service (≥1 nurse consultation for self-management advice) or (2) exercise advice and support (5–10 consultations with a physiotherapist trained in behaviour change for a personalised strengthening and physical activity programme) plus the existing service. Primary outcomes were overall knee pain (Numerical Rating Scale, range 0–10) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, range 0–68) at 6 months. Secondary outcomes, cost-effectiveness and 12-month follow-up were included. Results 165 (94%) and 158 (90%) participants were retained at 6 and 12 months, respectively. At 6 months, exercise advice and support resulted in greater improvement in function (mean difference 4.7 (95% CI 1.0 to 8.4)), but not overall pain (0.7, 0.0 to 1.4). Eight of 14 secondary outcomes favoured exercise advice and support at 6 months, including pain on daily activities, walking pain, pain self-efficacy, global improvements across multiple domains (overall improvement, improved pain, improved function and improved physical activity) and satisfaction. By 12 months, most outcomes were similar between groups. Exercise advice and support cost $A514/participant and did not save other health service resources. Conclusion Telephone-delivered physiotherapist-led exercise advice and support modestly improved physical function but not the co-primary outcome of knee pain at 6 months. Functional benefits were not sustained at 12 months. The clinical significance of this effect is uncertain. Trial registration number Australian New Zealand Clinical Trials Registry (#12616000054415).

中文翻译：

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物理治疗师通过电话提供的运动建议和支持是否可以改善膝骨关节炎患者的疼痛和/或功能？Telecare 随机对照试验

目的 评估物理治疗师主导的电话提供的针对膝骨关节炎患者的运动建议和支持干预。方法 参与者盲法、评估者盲法随机对照试验。175 人被随机分配到 (1) 现有电话服务（≥1 次护士咨询以获得自我管理建议）或 (2) 运动建议和支持（5-10 次咨询接受过行为改变训练的物理治疗师，以进行个性化的强化和身体活动计划）加上现有的服务。主要结果是 6 个月时的整体膝关节疼痛（数值评定量表，范围 0-10）和身体功能（西安大略和麦克马斯特大学骨关节炎指数，范围 0-68）。次要结果、成本效益和 12 个月的随访被包括在内。结果 分别有 165 (94%) 和 158 (90%) 名参与者在 6 个月和 12 个月时被保留。在 6 个月时，运动建议和支持导致了更大的功能改善（平均差异 4.7（95% CI 1.0 到 8.4）），但总体疼痛没有改善（0.7、0.0 到 1.4）。在 6 个月时，14 项次要结果中有 8 项支持运动建议和支持，包括日常活动疼痛、行走疼痛、疼痛自我效能、跨多个领域的整体改善（总体改善、疼痛改善、功能改善和身体活动改善）和满意度。到 12 个月时，组间的大多数结果相似。运动建议和支持费用为 A514/参与者，并没有节省其他卫生服务资源。结论 电话提供的物理治疗师主导的运动建议和支持适度改善了身体功能，但不是 6 个月时膝关节疼痛的共同主要结果。功能益处在 12 个月时没有持续。这种效应的临床意义尚不确定。试验注册号澳大利亚新西兰临床试验注册 (#12616000054415)。