Endocrine disrupting chemicals (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through their interaction with nuclear receptors such as the estrogen receptors α and β (ERα and ERβ), the androgen receptor (AR), the pregnan X receptor (PXR), the peroxisome proliferator activated receptors α and γ (PPARα, PPARγ) and the thyroid receptors α and β (TRα and TRβ). More recently, the retinoid X receptors (RXRα, RXRβ and RXRγ), the constitutive androstane receptor (CAR) and the estrogen related receptor γ (ERRγ) have also been identified as targets of EDCs. Finally, nuclear receptors still poorly studied for their interaction with environmental ligands such as the progesterone receptor (PR), the mineralocorticoid receptor (MR), the glucocorticoid receptor (GR), the retinoic acid receptors (RAR α, RARβ and RARγ), the farnesoid X receptor (FXR) and the liver X receptors α and β (LXRα and LXβ) as well are suspected targets of EDCs. Humans are generally exposed to low doses of pollutants, therefore the aim of current research is to identify the targets of EDCs at environmental concentrations. In this review, we analyze recent works referring that nuclear receptors are targets of EDCs and we highlight which EDCs are able to act at low concentrations.

中文翻译：

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核受体是破坏内分泌化学物质的主要目标。

内分泌干​​扰化学物质（EDC）是被怀疑对内分泌系统造成不良影响的外源性物质，主要是通过与诸如雌激素受体α和β（ERα和ERβ）的核受体，雄激素受体（AR）相互作用而起作用的， pregnan X受体（PXR），过氧化物酶体增殖物激活的受体α和γ（PPARα，PPARγ）和甲状腺受体α和β（TRα和TRβ）。最近，类视黄醇X受体（RXRα，RXRβ和RXRγ），组成型雄甾烷受体（CAR）和雌激素相关受体γ（ERRγ）也被确定为EDC的靶标。最后，对于核受体与环境配体如孕酮受体（PR），盐皮质激素受体（MR），糖皮质激素受体（GR），维甲酸受体（RARα，RARβ和RARγ），法呢素X受体（FXR）以及肝X受体α和β（LXRα和LXβ）也被认为是EDC的靶标。人类通常会暴露于低剂量的污染物，因此，当前研究的目的是确定环境浓度下EDC的目标。在这篇综述中，我们分析了最近的工作，这些工作指核受体是EDC的靶标，我们着重指出了哪些EDC能够在低浓度下起作用。