In 2015, professional guidelines defined the term 'likely pathogenic' to mean with a 90% chance of pathogenicity. To determine whether current practice reflects this definition, ClinVar classifications were tracked from 2016 to 2019. During that period, between 83.8 and 99.1% of likely pathogenic classifications were reclassified as pathogenic, depending on whether LP to VUS reclassifications are included and on how these classifications are categorized.

中文翻译：

---

“可能致病”真的有90％的可能性吗？ClinVar中的重分类数据。

2015年，专业准则将“可能致病”一词定义为具有90％的致病性机会。为了确定当前的实践是否反映了这一定义，从2016年到2019年追踪了ClinVar分类。在此期间，根据是否包括LP到VUS的重新分类以及这些分类的方式，将83.8％至99.1％的可能的病原分类重新分类为病原。归类。