Unawareness, or anosognosia, of memory deficits is a challenging manifestation of Alzheimer's disease (AD) that adversely affects a patient's safety and decision‐making. However, there is a lack of consensus regarding the presence, as well as the evolution, of altered awareness of memory function across the preclinical and prodromal stages of AD. Here, we aimed to characterize change in awareness of memory abilities and its relationship to beta‐amyloid (Aβ) burden in a large cohort (N = 1,070) of individuals across the disease spectrum.

中文翻译：

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阿尔茨海默病失认症的演变及其与淀粉样蛋白的关系

对记忆缺陷的无意识或失认症是阿尔茨海默病 (AD) 的一种具有挑战性的表现，会对患者的安全和决策产生不利影响。然而，对于 AD 的临床前和前驱阶段记忆功能意识改变的存在和演变缺乏共识。在这里，我们旨在表征整个疾病谱的大型队列（N = 1,070）中的记忆能力意识的变化及其与β-淀粉样蛋白（Aβ）负担的关系。