Research advances in tissue immunology have begun to decipher how organ physiology is integrated with resident immune cells during tissue development, healthspan and disease states. Here, we review a selection of studies from 2019 that highlight how resident lymphocytes communicate with epithelia, neurons and stromal cells in tissues to coordinate regional and systemic remodelling in response to local perturbations. Several studies from 2019 have highlighted emerging routes of communication between tissue-resident immune cells and local neurons, stromal cells, endothelial cells and epithelial cells to exert effects beyond the local tissue.

中文翻译：

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组织免疫力在远近传播。

组织免疫学的研究进展已开始破译在组织发育，健康期和疾病状态期间器官生理如何与驻留的免疫细胞整合在一起。在这里，我们回顾了2019年的一系列研究，这些研究着重介绍了常驻淋巴细胞如何与组织中的上皮细胞，神经元和基质细胞进行通讯，以协调区域和系统重塑以应对局部扰动。从2019年开始的几项研究强调了组织驻留免疫细胞与局部神经元，基质细胞，内皮细胞和上皮细胞之间交流的新兴途径，以发挥超出局部组织的作用。