Over the past decade, knowledge of cancer metabolism has expanded exponentially and has provided several clinically relevant targets for cancer therapy. Although these current approaches have shown promise, there are very few studies showing how seemingly unrelated metabolic processes in other diseases can readily occur in cancer. Moreover, the striking metabolic overlap between cancer and other diseases such as diabetes, cardiovascular, neurological, obesity, and aging has provided key therapeutic strategies that have even begun to be translated into clinical trials. These promising results necessitate consideration of the interconnected metabolic network while studying the metabolism of cancer. This review article discusses how cancer metabolism is intertwined with systemic metabolism and how knowledge from other diseases can help to broaden therapeutic opportunities for cancer.

在过去的十年中，关于癌症代谢的知识呈指数级增长，并为癌症治疗提供了几个临床相关的靶点。尽管这些当前的方法已显示出前景，但很少有研究表明其他疾病中看似不相关的代谢过程如何在癌症中容易发生。此外，癌症与糖尿病、心血管、神经系统、肥胖和衰老等其他疾病之间惊人的代谢重叠提供了关键的治疗策略，甚至已经开始转化为临床试验。这些有希望的结果需要在研究癌症代谢时考虑相互关联的代谢网络。