Chronic graft-versus-host disease (cGVHD) adversely affects patient quality of life, functional status, and survival after allogenic hematopoietic cell transplantation. The Lee Symptom Scale is a 30-item scale developed to measure the symptoms of cGVHD. Although the original 30-item scale uses a 1-month recall period, we tested the reliability and validity of a 28-item scale (deleting 2 items based on supportive care needs rather than symptoms) with a 7-day recall period, a format that is more appropriate for use in clinical trials. Results show the modified 7-day scale is reliable and valid in the modern era and may be used to assess the symptom burden of cGVHD in clinical trials. Using the distribution method, a 5- to 6-point difference (half a standard deviation) is considered clinically meaningful.

中文翻译：

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改良的7天Lee慢性移植物抗宿主疾病症状量表的可靠性和有效性。

异体造血细胞移植后，慢性移植物抗宿主病（cGVHD）对患者的生活质量，功能状态和生存产生不利影响。李症状量表是一项30项量表，旨在测量cGVHD的症状。尽管最初的30个项目的量表使用了1个月的召回期，但我们测试了28个项目的量表（根据支持性护理需求而不是症状删除2个项目）的可靠性和有效性，该形式具有7天的召回期，一种格式更适合用于临床试验。结果表明，修改后的7天量表在现代时代是可靠且有效的，可用于评估cGVHD的临床症状负担。使用分布方法，5点到6点的差异（标准差的一半）被认为具有临床意义。