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New cytotoxic limonoids from the stem bark of Chisocheton pentandrus (Blanco) Merr
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2019-11-20 , DOI: 10.1016/j.phytol.2019.11.002
Unang Supratman , Supriatno Salam , Wiro Naibaho , Mohamad Fajar , Nurlelasari , Dewa Gede Katja , Desi Harneti , Rani Maharani , Ace Tatang Hidayat , Ronny Lesmana , Mohamad Azlan Nafiah , Yoshihito Shiono

Three new limonoids namely pentandricines B–D (1–3), were isolated from n-hexane extract of the stem bark of Chisocheton pentandrus, along with four known limonoids (4-7). The chemical structures of pentandricines B–D, were fully elucidated based on UV, IR, HR-TOFMS, 1D- and 2D-NMR spectra. Furthermore, compounds 1-7 were evaluated for their cytotoxic activity against MCF-7 breast cancer cells in vitro, with compound 7 (nimonol) showing strongest cytotoxicity activity with an IC50 value of 22.03 ± 0.026 μM.



中文翻译:

五味茅草(Chisocheton pentandrus(Blanco)Merr)的茎皮中新的细胞毒性柠檬苦素

三个新的柠檬苦素即pentandricines B-d(1-3)中,从分离Ñ的茎皮的提取物正己烷溪桫属pentandrus,具有四个已知柠檬苦素(沿4-7) 。根据UV,IR,HR-TOFMS,1D和2D-NMR光谱,可以完全阐明戊三酮B–D的化学结构。此外,化合物1 - 7进行了评价它们对MCF-7乳腺癌细胞的细胞毒活性在体外,用化合物7(nimonol)表示与IC最强的细胞毒性活性的50 22.03±0.026μM的值。

更新日期:2019-11-20
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