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Western Diet and the Immune System: An Inflammatory Connection.
Immunity ( IF 32.4 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.immuni.2019.09.020
Anette Christ 1 , Mario Lauterbach 2 , Eicke Latz 3
Affiliation  

The consumption of Western-type calorically rich diets combined with chronic overnutrition and a sedentary lifestyle in Western societies evokes a state of chronic metabolic inflammation, termed metaflammation. Metaflammation contributes to the development of many prevalent non-communicable diseases (NCDs), and these lifestyle-associated pathologies represent a rising public health problem with global epidemic dimensions. A better understanding of how modern lifestyle and Western diet (WD) activate immune cells is essential for the development of efficient preventive and therapeutic strategies for common NCDs. Here, we review the current mechanistic understanding of how the Western lifestyle can induce metaflammation, and we discuss how this knowledge can be translated to protect the public from the health burden associated with their selected lifestyle.

中文翻译:

西方饮食与免疫系统:炎症联系。

在西方社会中,摄入西式热量丰富的饮食,加上长期的营养过剩和久坐的生活方式,唤起了一种慢性代谢性炎症的状态,称为代谢性炎症。易发炎导致许多流行的非传染性疾病(NCD)的发展,而这些与生活方式相关的疾病代表了全球流行问题日益严重的公共卫生问题。更好地了解现代生活方式和西方饮食(WD)如何激活免疫细胞对于开发常见NCD的有效预防和治疗策略至关重要。在这里,我们回顾了有关西方生活方式如何诱发发炎的当前机理理解,
更新日期:2019-11-20
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