In this study, a continuous-flow synthesis of the azo pigment Yellow 14 protocol has been developed using a three-stream micromixing process. This method controlled the pH of the azo coupling reaction process accurately and conveniently. After the optimization of the reaction conditions, the pigment products had a high purity and a good chromatic light. Compared with the two-stream micromixing process, the purity of the pigment products synthesized by the three-stream micromixing process increased by 9.41%, and the color differences between pigment products and Yellow 14 standard decreased obviously. Furthermore, the transparency numbers of pigment products synthesized by the microreactor system increased by 93–99% compared with that of the Yellow 14 standard. For the chromatic light, the red and blue hues of the pigment products were more intense than those of the Yellow 14 standard. Overall, the three-stream micromixing process led to an improvement of the pigment products, and this method also has good potential in industrial applications.

中文翻译：

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三流微混合工艺连续流合成偶氮颜料黄14

在这项研究中，使用三流微混合工艺开发了偶氮颜料黄14协议的连续流合成方法。该方法准确，方便地控制了偶氮偶合反应过程的pH。在优化反应条件之后，颜料产物具有高纯度和良好的彩色光。与两流微混合工艺相比，三流微混合工艺合成的颜料产品的纯度提高了9.41％，颜料产品与Yellow 14标准品之间的色差明显减小。此外，与黄色14标准液相比，微反应器系统合成的颜料产品的透明度值提高了93–99％。对于彩色光，颜料产品的红色和蓝色色调比黄色14标准的要强烈。总体而言，三流微混合工艺可改善颜料产品，该方法在工业应用中也具有良好的潜力。