Nanoscale vesicles functionalized with a nitric oxide (NO) releasing molecule 4-nitro-3-(trifluoromethyl)aniline have been reported. The new NO-nano-vesicular donor material shows an effective photo-release of NO upon irradiation with blue light at 410 nm. The kinetics of NO release has been monitored by using simple spectroscopic techniques such as UV-Vis and fluorescence methods. Colorimetric Griess assay and fluorescence DAF assay have been used for the detection and quantification of NO released from vesicles. This new vesicular nanoscale NO donor has the advantages of facile preparation in water, capable of releasing NO in a pure aqueous medium, photo-controlled NO release, bio-compatibility and capacity to modulate the NO donor loading to achieve an essential amount of NO.

中文翻译：

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用硝基苯胺衍生物功能化的纳米级脂质囊泡用于光诱导一氧化氮 (NO) 递送

已经报道了用一氧化氮 (NO) 释放分子 4-nitro-3-(trifluoromethyl)aniline 功能化的纳米级囊泡。新的 NO 纳米囊泡供体材料在 410 nm 的蓝光照射下显示出有效的 NO 光释放。已通过使用简单的光谱技术（如 UV-Vis 和荧光方法）监测 NO 释放的动力学。比色 Griess 测定和荧光 DAF 测定已用于检测和量化从囊泡释放的 NO。这种新型囊泡纳米级 NO 供体具有易于在水中制备、能够在纯水介质中释放 NO、光控 NO 释放、生物相容性和调节 NO 供体负载以实现必需量 NO 的优点。