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Sexual function in long-term male lymphoma survivors after high-dose therapy with autologous stem-cell transplantation.
Bone Marrow Transplantation ( IF 4.8 ) Pub Date : 2019-11-19 , DOI: 10.1038/s41409-019-0745-4
Hanne Skjerven Bersvendsen 1, 2 , Hege Sagstuen Haugnes 1, 2 , Alv A Dahl 3, 4 , Unn-Merete Fagerli 5, 6 , Øystein Fluge 7 , Harald Holte 8, 9 , Mette Seland 3 , Tom Wilsgaard 10 , Knut Bjøro Smeland 3 , Cecilie Essholt Kiserud 3
Affiliation  

Reduced sexual function may have negative implications on health related quality of life among lymphoma survivors. A national cross-sectional study among long-term lymphoma survivors after high-dose therapy with autologous stem-cell transplantation auto-SCT treated during 1987-2008 was conducted in 2012-2014. The current study explored sexual functioning among these survivors. Sixty-six percent (n = 159) of eligible men with complete questionnaire data were included, median age was 55 years. The Brief Sexual Function Inventory (BSFI) was used to assess sexual function and sexual satisfaction, compared with age-matched controls. In addition, sexual problems were defined based on predetermined cutoff values for BSFI domain scores. Sexual drive and erections firm enough to have sexual intercourse were reported to be present only a few days or less last month among 30% and 41% of survivors, respectively. Sexual satisfaction was reported by 39% of survivors. The survivors had significantly lower scores on all BSFI domains and an increased risk of problems with sexual drive and erection compared with controls. In multivariable models, cardiovascular disease was significantly associated with worse erectile function, while age > 55 years, chronic fatigue, and physical inactivity were significantly associated with lower sexual functioning overall. Chronic fatigue and anxiety were related to lower sexual satisfaction.

中文翻译:

自体干细胞移植大剂量治疗后长期男性淋巴瘤幸存者的性功能。

性功能下降可能会对淋巴瘤幸存者的健康相关生活质量产生负面影响。在2012-2014年间进行了一项全国性横断面研究,研究对象是在1987-2008年间接受自体干细胞移植auto-SCT大剂量治疗后的长期淋巴瘤幸存者。当前的研究探讨了这些幸存者之间的性功能。包括百分之六十六(n = 159)的具有完整问卷数据的合格男性,中位年龄为55岁。与年龄匹配的对照组相比,使用了简短的性功能清单(BSFI)来评估性功能和性满意度。此外,根据预定的BSFI域得分临界值定义了性问题。据报道,上个月在30%和41%的幸存者中,只有足够几天才能发生性交的性冲动和勃起才发生。39%的幸存者报告了性满足感。与对照组相比,幸存者在所有BSFI域上的得分均明显较低,并且发生性欲和勃起问题的风险增加。在多变量模型中,心血管疾病与勃起功能恶化显着相关,而年龄> 55岁,慢性疲劳和缺乏身体活动与总体性功能下降显着相关。慢性疲劳和焦虑与较低的性满意度有关。与对照组相比,幸存者在所有BSFI域上的得分均明显较低,并且发生性欲和勃起问题的风险增加。在多变量模型中,心血管疾病与勃起功能恶化显着相关,而年龄> 55岁,慢性疲劳和缺乏身体活动与总体性功能下降显着相关。慢性疲劳和焦虑与较低的性满意度有关。与对照组相比,幸存者在所有BSFI域上的得分均明显较低,并且发生性欲和勃起问题的风险增加。在多变量模型中,心血管疾病与勃起功能恶化显着相关,而年龄大于55岁,慢性疲劳和缺乏身体活动与总体性功能下降显着相关。慢性疲劳和焦虑与较低的性满意度有关。
更新日期:2019-11-20
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