The myocardium is a highly structured pluricellular tissue which is governed by an intricate network of intercellular communication. Endothelial cells are the most abundant cell type in the myocardium and exert crucial roles in both healthy myocardium and during myocardial disease. In the last decade, microRNAs have emerged as new actors in the regulation of cellular function in almost every cell type. Here, we review recent evidence on the regulatory function of different microRNAs expressed in endothelial cells, also called endothelial microRNAs, in healthy and diseased myocardium. Endothelial microRNA emerged as modulators of angiogenesis in the myocardium, they are implicated in the paracrine role of endothelial cells in regulating cardiac contractility and homeostasis, and interfere in the crosstalk between endothelial cells and cardiomyocytes.

中文翻译：

---

内皮miRNA在心肌生物学和疾病中的作用。

心肌是高度结构化的多细胞组织，由复杂的细胞间通讯网络控制。内皮细胞是心肌中最丰富的细胞类型，在健康心肌和心肌疾病中均起着至关重要的作用。在过去的十年中，microRNA已成为调节几乎所有细胞类型的细胞功能的新角色。在这里，我们回顾了有关健康和患病心肌中内皮细胞（也称为内皮微RNA）中表达的不同微RNA调控功能的最新证据。内皮microRNA在心肌中作为血管生成的调节剂出现，它们与内皮细胞在调节心脏收缩力和体内稳态中的旁分泌作用有关，