Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photosensitizer (PS); historically, a purely organic macrocyclic tetrapyrrole-based structure. This short review surveys two recent clinical examples of metal complexes, namely TOOKAD®-Soluble and TLD-1433, which have ideal photophysical properties to act as PDT PSs. We highlight the important role played by the metal ions in the PS for PDT activity.

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用于光动力疗法的金属基光敏剂：多峰肿瘤学的未来？

光动力疗法（PDT）是一种经过批准的医学技术，可以治疗某些形式的癌症。它已被用来补充传统的抗癌方式，例如手术，化学疗法或放射疗法，在某些情况下还可以替代这些疗法。PDT的一个关键参数是光敏剂（PS）。历史上是纯有机大环四吡咯基结构。这篇简短的评论调查了金属络合物的两个最新临床实例，即TOOKAD®-Soluble和TLD-1433，它们具有理想的光物理性质，可以用作PDT PS。我们强调了金属离子在PS中对PDT活性的重要作用。