The relative efficacy of different antiretroviral (ART) regimens has been extensively evaluated in the context of clinical trials, using HIV viral load (VL) measurements at pre‐specified timepoints after ART onset. However, data from real‐life studies using combined longitudinal measurements of cumulative viraemia are scarce. This study aimed to address the independent effect of different ART regimens on HIV cumulative viraemia over the first 12 months after treatment initiation, using programmatic data from the Ministry of Health of Brazil.

中文翻译：

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不同抗逆转录病毒方案治疗开始后累积病毒血症的比较：巴西的一项真实研究

不同抗逆转录病毒 (ART) 方案的相对疗效已在临床试验的背景下进行了广泛评估，在 ART 开始后的预先指定时间点使用 HIV 病毒载量 (VL) 测量值。然而，使用累积病毒血症的联合纵向测量的现实研究数据很少。本研究旨在利用巴西卫生部的计划数据，探讨不同 ART 方案在治疗开始后的前 12 个月内对 HIV 累积病毒血症的独立影响。