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Increase in adiposity from childhood to adulthood predicts a metabolically obese phenotype in normal-weight adults
International Journal of Obesity ( IF 4.9 ) Pub Date : 2019-11-19 , DOI: 10.1038/s41366-019-0479-9
A Viitasalo 1, 2, 3 , N Pitkänen 2, 3 , K Pahkala 2, 3, 4 , T Lehtimäki 5, 6 , J S A Viikari 7 , O Raitakari 2, 3, 8 , T O Kilpeläinen 1
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Normal weight is associated with a favorable cardiometabolic risk profile and low risk of type 2 diabetes and cardiovascular disease. However, some normal-weight individuals—the “metabolically obese normal weight” (MONW)—show a cardiometabolic risk profile similar to the obese. Previous studies have shown that older age, central body fat distribution, and unfavorable lifestyle increase the risk of MONW. However, the role of early-life factors in MONW remains unknown. We examined the associations of early-life factors with adult MONW in 1178 individuals from the Cardiovascular Risk in Young Finns study who were followed up from childhood to adulthood. The strongest early predictor for adult MONW was an increase in BMI from childhood to adulthood (p = 3.1 × 10−11); each 1 SD increase in BMI z-score from childhood to adulthood led to a 2.56-fold increase in the risk of adult MONW (CI 95% = 1.94–3.38). Other significant predictors of adult MONW were male sex (OR = 2.38, 95% = 1.63–3.47, p = 7.0 × 10−6), higher childhood LDL cholesterol (OR = 1.41 per 1 SD increase in LDL cholesterol, CI 95% = 1.14–1.73, p = 0.001), and lower HDL cholesterol (OR = 1.51 per 1 SD decrease in HDL cholesterol, CI 95% = 1.23–1.85, p = 5.4 × 10−5). Our results suggest that an increase in adiposity from childhood to adulthood is detrimental to cardiometabolic health, even among individuals remaining normal weight.



中文翻译:

从儿童期到成年期肥胖的增加预示着正常体重成年人的代谢性肥胖表型

正常体重与良好的心脏代谢风险和低 2 型糖尿病和心血管疾病风险相关。然而,一些正常体重的个体——“代谢性肥胖的正常体重”(MONW)——表现出与肥胖者相似的心脏代谢风险特征。先前的研究表明,年龄较大、中心体脂肪分布和不利的生活方式会增加 MONW 的风险。然而,早期生活因素在 MONW 中的作用仍然未知。我们检查了来自年轻芬兰人心血管风险研究的 1178 名个体的早期生活因素与成年 MONW 的关联,这些个体从儿童期到成年期都进行了随访。成人 MONW 的最强早期预测因子是从儿童期到成年期 BMI 的增加(p  = 3.1 × 10 -11); 从儿童期到成年期,BMI z值每增加 1 个 SD ,成年 MONW 的风险就会增加 2.56 倍(CI 95% = 1.94-3.38)。成年 MONW 的其他重要预测因素是男性(OR = 2.38, 95% = 1.63–3.47, p  = 7.0 × 10 -6)、较高的儿童低密度脂蛋白胆固醇(低密度脂蛋白胆固醇每 1 SD 增加,OR = 1.41,CI 95% = 1.14–1.73, p  = 0.001),降低 HDL 胆固醇(OR = 1.51 每 1 SD HDL 胆固醇降低,CI 95% = 1.23–1.85,p  = 5.4 × 10 -5)。我们的研究结果表明,从儿童期到成年期肥胖的增加对心脏代谢健康有害,即使在体重保持正常的个体中也是如此。

更新日期:2019-11-19
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