The influence of advanced glycation end products (AGEs) in the biological processes contribute to the life-changing complications such as progression of cancer, diabetes and other chronic disorders. The receptor of AGEs while interacting with its ligands causes a never-ending irregularity in the cell-signaling communication. Hence, AGEs are considered as an important link between progression and contribution to cancer. This study focuses on the presence and/or absence of oxidative and glycative stress in the serum samples of various cancer patients. During analysis of the early and intermediate glycation product in cancer patient's sera, our result indicates an increasing trend of both the adducts as compared to normal healthy subjects. Similarly, one of the AGEs i.e., carboxymethyllysine was found to be enhanced in cancer sera as compared to NHS. The binding characteristics of circulating auto-antibodies in cancer patient's sera against human serum albumin (HSA)-AGEs were assessed through ELISA and furthermore, the maximum percent inhibition against HSA-AGEs was observed as 57-63%, 46-62% and 42-64% in prostate cancer, lung cancer and head and neck cancer. Hence, our result successfully assisted the presence of AGEs in all the cancer patient's sera though it is not clear which specific cancer is more potent to AGEs.

中文翻译：

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癌症患者血清的糖氧化特性：将糖基化与癌症相关联的临床结果。

晚期糖基化终产物（AGEs）在生物过程中的影响助长了改变生活的并发症，例如癌症，糖尿病和其他慢性疾病的进展。AGEs的受体与其配体相互作用时，会在细胞信号通讯中引起永无止境的不规则现象。因此，AGEs被认为是癌症进展与贡献之间的重要纽带。这项研究的重点是各种癌症患者的血清样本中是否存在氧化应激和糖化应激。在分析癌症患者血清中的早期和中期糖基化产物时，我们的结果表明与正常健康受试者相比，这两种加合物的趋势都有所增加。同样，其中一个年龄段，即 与NHS相比，发现羧甲基赖氨酸在癌症血清中具有增强作用。通过ELISA评估癌症患者血清中循环自身抗体对人血清白蛋白（HSA）-AGE的结合特性，此外，观察到对HSA-AGEs的最大抑制百分比为57-63％，46-62％和42 -64％在前列腺癌，肺癌和头颈癌中。因此，尽管尚不清楚哪种特定的癌症对AGEs更有效，我们的结果成功地帮助了所有癌症患者血清中AGEs的存在。肺癌和头颈癌。因此，尽管尚不清楚哪种特定的癌症对AGEs更有效，我们的结果成功地帮助了所有癌症患者血清中AGEs的存在。肺癌和头颈癌。因此，尽管尚不清楚哪种特定的癌症对AGEs更有效，我们的结果成功地帮助了所有癌症患者血清中AGEs的存在。