Electrophilic trifluoromethylthiolation has emerged as an important and efficient methodology for installing the SCF₃ moiety onto an array of organic molecules. Due to the low reactivities of trifluoromethylthiolating reagents, these transformations often require activation through an exogenous Lewis/Brønsted acid. We report herein the quantification of the activation capabilities of Lewis/Brønsted acids for trifluoromethylthiolating reagents through computing the difference in trifluoromethylthio cation donor ability (Tt⁺DA) between the "activated” and “unactivated” reagent. A moderate correlation is found to exist between the activation capability and Lewis acidity.

中文翻译：

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路易斯/布朗斯台德酸对亲电子三氟甲基硫醇化试剂的活化能力的定量分析†

亲电子三氟甲基硫醇化已成为一种重要且有效的方法，用于将SCF ₃部分安装到有机分子阵列上。由于三氟甲基硫醇化试剂的反应性低，这些转化通常需要通过外源的路易斯/布朗斯台德酸进行活化。我们通过计算“活化”和“未活化”试剂之间三氟甲硫基阳离子供体能力（Tt ⁺ DA）的差异，报告了路易斯/布朗斯台德酸对三氟甲硫基化试剂的活化能力的定量。活化能力和路易斯酸度。