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Gut Check Time: Antibiotic Delivery Strategies to Reduce Antimicrobial Resistance
Trends in Biotechnology ( IF 17.3 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.tibtech.2019.10.008
Stephen A Kelly 1 , Aoife M Rodgers 2 , Séamus C O'Brien 1 , Ryan F Donnelly 1 , Brendan F Gilmore 1
Affiliation  

Antimicrobial resistance (AMR) has developed into a huge threat to global health, and reducing it is an urgent priority for public health authorities. The importance of a healthy and balanced gut microbiome has been identified as a key protective factor against AMR development, but this can be significantly affected by antibiotic therapy, resulting in dysbiosis and reduction of taxonomic richness. The way in which antibiotics are administered could form an important part of future antimicrobial stewardship strategies, where drug delivery is ideally placed to play a key role in the fight against AMR. This review focuses on drug delivery strategies for antibiotic administration, including avoidance of the gut microbiome and targeted delivery approaches, which may reduce AMR.



中文翻译:

肠道检查时间:减少抗生素耐药性的抗生素给药策略

抗菌素耐药性 (AMR) 已发展成为对全球健康的巨大威胁,减少它是公共卫生当局的当务之急。健康和平衡的肠道微生物组的重要性已被确​​定为防止 AMR 发展的关键保护因素,但这可能会受到抗生素治疗的显着影响,导致生态失调和分类丰富度降低。抗生素的给药方式可能会成为未来抗菌药物管理策略的重要组成部分,其中理想的给药方式是在抗击 AMR 的斗争中发挥关键作用。本综述侧重于抗生素给药的给药策略,包括避免肠道微生物组和靶向给药方法,这可能会降低 AMR。

更新日期:2019-11-19
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