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New Structures Reveal Interaction Dynamics in Respiratory Supercomplexes.
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.tibs.2019.10.011 Peter Brzezinski 1
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.tibs.2019.10.011 Peter Brzezinski 1
Affiliation
Mitochondrial energy conversion involves a chain of membrane-bound proteins that are wired to conduct an electron current, which drives transmembrane proton translocation. These enzymes associate to form supercomplexes, but the functional relevance of the higher-order structures is unknown. A recent study by Letts et al. presents structures of a supercomplex, which suggest how the interaction choreography may control overall functionality.
中文翻译:
新结构揭示了呼吸超复合物中的相互作用动力学。
线粒体能量转换涉及一连串的膜结合蛋白,这些蛋白被连接传导电子电流,从而驱动跨膜质子易位。这些酶结合形成超复合物,但是高阶结构的功能相关性尚不清楚。Letts等人的最新研究。提出了一种超级复合体的结构,这表明了交互编排如何控制整体功能。
更新日期:2019-11-19
中文翻译:
新结构揭示了呼吸超复合物中的相互作用动力学。
线粒体能量转换涉及一连串的膜结合蛋白,这些蛋白被连接传导电子电流,从而驱动跨膜质子易位。这些酶结合形成超复合物,但是高阶结构的功能相关性尚不清楚。Letts等人的最新研究。提出了一种超级复合体的结构,这表明了交互编排如何控制整体功能。