Abstract The addition of an aqueous solution of palladium chloride to an aqueous acetonitrile solution of 4-acetylpyridine (4-Acpy) and KSCN or NaN3 produces new complexes, [Pd(SCN)2(4-Acpy)2] (1) and [Pd(N3)2(4-Acpy)2] (2), at ambient conditions. Complexes 1 and 2 were characterized by elemental analysis, FT-IR, and UV-Visible spectra. The structures of 1 and 2 were determined by single crystal X-ray diffraction. The coordination geometry around the palladium center is distorted square planar in 1 and 2 as the palladium is coordinated with two 4-acetylpyridine and two thiocyanates in 1 or two azide groups in 2. The discrete units of 1 and 2 extend along the a-axis creating a 1 D-chain via non-covalent hydrogen bonds. The extensive non-covalent hydrogen bonds extend the structure of 1 and 2 to 3D-networks. Using MTT assay, the cytotoxic activities of 1 and 2 were screened against two cancer cell lines, HePG-2 (liver cancer) and MCF-7 (breast cancer). The MTT assay revealed that the cytotoxic activity of 1 is stronger than 2 for HePG-2 and MCF-7. Antioxidant and anti‐hemolytic activities of 1 and 2 were examined. Furthermore, the luminescence spectra in the solid state of 1 and 2 are discussed.

中文翻译：

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4-乙酰基吡啶假卤化钯配合物的结构表征和抗肿瘤活性

摘要 将氯化钯水溶液加入到 4-乙酰吡啶 (4-Acpy) 和 KSCN 或 NaN3 的乙腈水溶液中会产生新的配合物 [Pd(SCN)2(4-Acpy)2] (1) 和 [ Pd(N3)2(4-Acpy)2] (2)，在环境条件下。配合物 1 和 2 通过元素分析、FT-IR 和紫外-可见光谱表征。1和2的结构由单晶X射线衍射确定。钯中心周围的配位几何形状在 1 和 2 中是扭曲的方形平面，因为钯与 1 中的两个 4-乙酰吡啶和两个硫氰酸酯或 2 中的两个叠氮化物基团配位。 1 和 2 的离散单元沿 a 轴延伸通过非共价氢键创建 1 D 链。广泛的非共价氢键将 1 和 2 的结构扩展到 3D 网络。使用 MTT 测定，针对两种癌细胞系 HePG-2（肝癌）和 MCF-7（乳腺癌）筛选了 1 和 2 的细胞毒活性。MTT 分析表明，1 的细胞毒活性强于 HePG-2 和 MCF-7 的 2。检查了 1 和 2 的抗氧化和抗溶血活性。此外，还讨论了 1 和 2 的固态发光光谱。