Due to the variable overlap of multiple symptoms, accurate early diagnosis of NK/T-cell lymphoma-associated hemophagocytic syndrome (NK/T-LAHS) is difficult, making the prognosis extremely poor. Hemophagocytic syndrome (HPS) is now diagnosed primarily based on the hemophagocytic lymphohistiocytosis (HLH)-2004 diagnostic criteria, and platelet count is one of the baseline evaluations. However, in our study, the data showed that decreased platelets were not only a clinical feature of HPS but also the key cells that regulate inflammation by releasing α-granules containing upregulated platelet factor 4 (PF4) and downregulated platelet-derived growth factors (PDGFs). Furthermore, we found that angiopoietin-4 (ANG-4), which has significant differential expression, has been less reported, that may affect hematopoiesis and proinflammatory responses and can be used as diagnostic biomarkers together with PF4 and PDGFs.

中文翻译：

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血小板衍生的 α-颗粒与 NK/T 细胞淋巴瘤相关的噬血细胞综合征患者的炎症有关

由于多种症状的可变重叠，NK/T细胞淋巴瘤相关噬血细胞综合征（NK/T-LAHS）的准确早期诊断困难，预后极差。噬血细胞综合征 (HPS) 现在主要根据噬血细胞淋巴组织细胞增生症 (HLH)-2004 诊断标准进行诊断，血小板计数是基线评估之一。然而，在我们的研究中，数据显示血小板减少不仅是 HPS 的临床特征，而且是通过释放含有上调血小板因子 4 (PF4) 和下调血小板衍生生长因子 (PDGFs) 的α-颗粒来调节炎症的关键细胞。 ）。此外，我们发现具有显着差异表达的血管生成素-4（ANG-4）的报道较少，