OBJECTIVE Many studies suggest a strong familial component to fibromyalgia (FM). However, those studies have nearly all been confined to individuals with primary FM, i.e., FM without any other accompanying disorder. The current 2011 and 2016 criteria for diagnosing FM construct a score using a combination of the number of painful body sites and the severity of somatic symptoms (FM score). This study was undertaken to estimate the genetic heritability of the FM score across sex and age groups to identify subgroups of individuals with greater heritability, which may help in the design of future genetic studies. METHODS We collected data on 26,749 individuals of European ancestry undergoing elective surgery at the University of Michigan (Michigan Genomics Initiative study). We estimated the single-nucleotide polymorphism-based heritability of FM score by age and sex categories using genome-wide association study data and a linear mixed-effects model. RESULTS Overall, the FM score had an estimated heritability of 13.9% (SE 2.9%) (P = 1.6 × 10-7 ). Estimated FM score heritability was highest in individuals ≤50 years of age (23.5%; SE 7.9%) (P = 3.0 ×10-4 ) and lowest in individuals >60 years of age (7.5%; SE 8.1%) (P = 0.41). These patterns remained the same when we analyzed FM as a case-control phenotype. Even though women had an ~30% higher average FM score than men across age categories, FM score heritability did not differ significantly by sex. CONCLUSION Younger individuals appear to have a much stronger genetic component to the FM score than older individuals. Older individuals may be more likely to have what was previously called "secondary FM." Regardless of the cause, these results have implications for future genetic studies of FM and associated conditions.

中文翻译：

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纤维肌痛表型的遗传性因年龄而异。

目的 许多研究表明纤维肌痛 (FM) 具有很强的家族性。然而，这些研究几乎都局限于患有原发性 FM 的个体，即没有任何其他伴随疾病的 FM。当前 2011 年和 2016 年诊断 FM 的标准使用身体疼痛部位的数量和躯体症状的严重程度（FM 评分）的组合构建了一个评分。本研究旨在评估跨性别和年龄组的 FM 评分的遗传遗传力，以确定具有更大遗传力的个体亚组，这可能有助于设计未来的遗传研究。方法 我们收集了 26,749 名在密歇根大学接受择期手术的欧洲血统个体的数据（密歇根基因组学倡议研究）。我们使用全基因组关联研究数据和线性混合效应模型按年龄和性别类别估计了基于单核苷酸多态性的 FM 评分的遗传力。结果 总体而言，FM 评分的估计遗传率为 13.9% (SE 2.9%) (P = 1.6 × 10-7)。估计 FM 评分遗传力在 ≤ 50 岁的个体 (23.5%; SE 7.9%) (P = 3.0 ×10-4) 中最高，在 >60 岁的个体中最低 (7.5%; SE 8.1%) (P = 0.41）。当我们将 FM 作为病例对照表型进行分析时，这些模式保持不变。尽管女性在不同年龄段的平均 FM 得分比男性高约 30%，但 FM 得分的遗传力并没有因性别而有显着差异。结论 年轻个体似乎比年长个体对 FM 评分具有更强的遗传成分。老年人可能更有可能患有以前称为“二级 FM”的疾病。无论原因如何，这些结果对未来对 FM 和相关疾病的遗传研究都有影响。