The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent chemotaxis and metastasis of pancreatic cancer cells.

中文翻译：

---

N-WASP引导癌细胞走向LPA。

肌动蛋白重塑因子N-WASP在诸如胞吞作用，细胞外基质降解和宿主-病原体相互作用等过程中被称为Arp2 / 3复合激活剂。在本期《发育细胞》中，Juin等人。建立N-WASP的新型运输功能，以驱动溶血磷脂酸依赖性胰腺癌细胞的趋化性和转移。