当前位置: X-MOL 学术Dev. Cell › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Dynamic Polarization of the Multiciliated Planarian Epidermis between Body Plan Landmarks.
Developmental Cell ( IF 11.8 ) Pub Date : 2019-11-18 , DOI: 10.1016/j.devcel.2019.10.022
Hanh Thi-Kim Vu 1 , Sarah Mansour 1 , Michael Kücken 2 , Corinna Blasse 1 , Cyril Basquin 3 , Juliette Azimzadeh 3 , Eugene Wimberly Myers 4 , Lutz Brusch 2 , Jochen Christian Rink 5
Affiliation  

Polarity is a universal design principle of biological systems that manifests at all organizational scales, yet its coordination across scales remains poorly understood. Here, we make use of the extreme anatomical plasticity of planarian flatworms to probe the interplay between global body plan polarity and local cell polarity. Our quantitative analysis of ciliary rootlet orientation in the epidermis reveals a dynamic polarity field with head and tail as independent determinants of anteroposterior (A/P) polarization and the body margin as determinant of mediolateral (M/L) polarization. Mathematical modeling rationalizes the global polarity field and its response to experimental manipulations as superposition of separate A/P and M/L fields, and we identify the core PCP and Ft/Ds pathways as their molecular mediators. Overall, our study establishes a framework for the alignment of cellular polarity vectors relative to planarian body plan landmarks and establishes the core PCP and Ft/Ds pathways as evolutionarily conserved 2D-polarization module.

中文翻译:

人体平面图地标之间多纤毛平面表皮的动态极化。

极性是生物系统的普遍设计原则,它在所有组织规模上均表现出来,但其在各个规模上的协调性仍然知之甚少。在这里,我们利用planar虫扁虫的极端解剖可塑性来探究整体人体计划极性与局部细胞极性之间的相互作用。我们对表皮睫状小根取向的定量分析揭示了动态极性场,其中头和尾是前后(A / P)极化的独立决定因素,而身体边缘是中外侧(M / L)极化的决定因素。数学建模合理化了全局极性场及其对实验操作的响应,将其作为单独的A / P和M / L场的叠加,并且我们确定了核心PCP和Ft / Ds途径是它们的分子介体。全面的,
更新日期:2019-11-18
down
wechat
bug