Integrins promote cell adhesion and migration, but also control local activation of latent transforming growth factor (TGF)-β contained in extracellular matrix or cell-surface reservoirs. Integrin-dependent activation of TGF-β has emerged as a crucial mechanism whereby tissue-borne cells instruct circulating and resident immune cells. Moreover, this regulation has wide pathophysiological implications in wound healing, tissue fibrosis, antibody production, pathogen clearance, inflammation, autoimmunity, cancer, and possibly metabolic disorders including diabetes. Here we review the spatiotemporal control of TGF-β activation by integrins, and its effects on immune cell signaling and function. We discuss the underlying molecular and cell-biological mechanisms, the implications for human health and disease, and possibilities for future therapeutic exploitation.

中文翻译：

---

通过整联蛋白依赖性调节TGF-β来控制免疫和炎症。

整联蛋白促进细胞粘附和迁移，但也控制细胞外基质或细胞表面贮藏物中所含的潜在转化生长因子（TGF）-β的局部活化。整联蛋白依赖性的TGF-β激活已成为一种重要的机制，由此组织传播的细胞可指导循环和驻留的免疫细胞。此外，该调节在伤口愈合，组织纤维化，抗体产生，病原体清除，炎症，自身免疫，癌症以及可能的代谢紊乱包括糖尿病中具有广泛的病理生理意义。在这里，我们审查了整联蛋白TGF-β激活的时空控制，及其对免疫细胞信号传导和功能的影响。我们讨论了潜在的分子和细胞生物学机制，对人类健康和疾病的影响，