We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.

中文翻译：

---

螺噻唑烷二酮类化合物的多样性导向合成及其生物学评价

我们报告了一种新的合成方法，可通过[2 + 2 + 2]环三聚反应组装螺噻唑烷二酮，并通过DA化学和点击反应进一步将衍生物官能化。使用流式细胞仪首次证明，此处生成的新的噻唑烷-2,4-二酮苄醇衍生物是HeLa，Hek293，U937，Jurkat和K562细胞系中有效的凋亡诱导剂。