Nanoemulgels are composed of O/W nanoemulsion and hydrogels and are considered as ideal carriers for the transdermal drug delivery because these have high affinity to load hydrophobic drugs. The stable formulation of eprinomectin (EPR) is very challenging because of it is high hydrophobic nature. In this work, we have prepared EPR loaded nanoemulgel for the treatment of endo- and ectoparasites. The surface morphology of optimized formulations was characterized by scanning electron microscopy. Additionally, skin permeability and irritation tests were conducted for in vitro safety and in vivo skin retention and pearmeation test of EPR nanoemulgel were conducted for efficacy study. Obtained results indicated that the optimized formulation had good shear-thinning behavior, bioadhesiveness properties, and are nanosized droplets with porous internal structure, which are required for topical application. Furthermore, this formulation has showed good skin permeability in comparison to suspension and has no skin irritating property. Overall, the obtained results proved that nanoemulgel is a promising carrier for transdermal drug delivery and EPR nanoemulgel is a promising formulation for the treatment of endo- and ectoparasites.

中文翻译：

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依普诺菌素纳米乳胶用于针对体内寄生虫和体外寄生虫的透皮递送：制备，体外和体内评估。

纳米乳剂由O / W纳米乳剂和水凝胶组成，被认为是透皮药物递送的理想载体，因为它们对负载疏水性药物具有很高的亲和力。依普连菌素（EPR）的稳定配方具有很高的疏水性，因此非常具有挑战性。在这项工作中，我们准备了EPR负载的纳米乳胶，用于治疗体内和体外寄生虫。通过扫描电子显微镜对优化配方的表面形貌进行了表征。另外，进行了皮肤渗透性和刺激性测试以用于体外安全性，并且进行了EPR纳米乳胶的体内皮肤保留性和渗透性测试以进行功效研究。所得结果表明，优化配方具有良好的剪切稀化行为，生物粘附性能，并且是具有多孔内部结构的纳米尺寸的液滴，这是局部应用所必需的。此外，与悬浮液相比，该制剂显示出良好的皮肤渗透性，并且没有皮肤刺激性。总的来说，所获得的结果证明纳米乳胶是用于透皮药物递送的有前途的载体，而EPR纳米乳胶是用于治疗内寄生虫和外寄生虫的有前途的制剂。