Temperature serves as a fundamental signal in biological systems. In some microbial pathogens of humans, mammalian body temperature triggers establishment and maintenance of a developmental program that allows the microbe to survive and thrive in the host. Histoplasma capsulatum is one of a group of fungal pathogens called thermally dimorphic fungi, all of which respond to mammalian body temperature by converting from an environmental mold form that inhabits the soil into a parasitic form that causes disease in the host. It has been known for decades that temperature is a key signal that is sufficient to trigger the switch from the soil to host form (and vice versa) in the laboratory. Recent molecular studies have identified a number of key regulators that are required to specify each of the developmental forms in response to temperature. Here we review the regulatory circuits that govern temperature-dependent dimorphism in Histoplasma.

中文翻译：

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组织胞浆二态性的分子调控。

温度是生物系统中的基本信号。在人类的某些微生物病原体中，哺乳动物的体温触发建立和维持一种发育程序，该程序使微生物能够在宿主中生存和繁衍。荚膜组织胞浆菌是被称为热二态性真菌的一组真菌病原体之一，所有这些病原体均通过从栖息在土壤中的环境霉菌形式转变为引起宿主疾病的寄生虫形式而对哺乳动物的体温作出反应。几十年来，众所周知，温度是一个关键信号，足以触发实验室中从土壤到宿主形态的转换（反之亦然）。最近的分子研究已经确定了许多关键调节剂，它们需要根据温度来指定每种发育形式。