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The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.
Ageing Research Reviews ( IF 13.1 ) Pub Date : 2019-11-15 , DOI: 10.1016/j.arr.2019.100983
Pedro Gomes 1 , Sofia D Viana 2 , Sara Nunes 3 , Anabela P Rolo 4 , Carlos M Palmeira 4 , Flávio Reis 3
Affiliation  

Aging, the most important risk factor for many of the chronic diseases affecting Western society, is associated with a decline in mitochondrial function and dynamics. Sirtuin 3 (SIRT3) is a mitochondrial deacetylase that has emerged as a key regulator of fundamental processes which are frequently dysregulated in aging and related disorders. This review highlights recent advances and controversies regarding the yin and yang functions of SIRT3 in metabolic, cardiovascular and neurodegenerative diseases, as well as the use of SIRT3 modulators as a therapeutic strategy against those disorders. Although most studies point to a protective role upon SIRT3 activation, there are conflicting findings that need a better elucidation. The discovery of novel SIRT3 modulators with higher selectivity together with the assessment of the relative importance of different SIRT3 enzymatic activities and the relevance of crosstalk between distinct sirtuin isoforms will be pivotal to validate SIRT3 as a useful drug target for the prevention and treatment of age-related diseases.



中文翻译:

年龄相关疾病中线粒体脱乙酰基酶Sirtuin 3的阴阳面。

衰老是影响西方社会的许多慢性疾病的最重要风险因素,与线粒体功能和动力学的下降有关。Sirtuin 3(SIRT3)是一种线粒体脱乙酰基酶,已成为基本过程的关键调节剂,这些过程在衰老和相关疾病中经常失调。这篇综述着重介绍了SIRT3在代谢,心血管和神经退行性疾病中的阴阳功能方面的最新进展和争议,以及SIRT3调节剂作为针对这些疾病的治疗策略的应用。尽管大多数研究都指出了SIRT3激活的保护作用,但仍有矛盾的发现需要更好地阐明。

更新日期:2019-11-15
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