Dithiocarbamates (DTCs) like mancozeb (MZ) and disulfiram (DS) are used throughout agriculture and medicine and have been implicated in neurotoxicity. Little research has been studied on the reported myopathies caused by these compounds. Their pathogenesis and mechanism of muscle toxicity has not been fully studied. The aim of this study is to investigate if DTCs alter striated muscle tissues in vivo. Long-Evans rats were treated with either MZ or DS followed by analysis of muscle biomarkers and metal levels. DS resulted in increases in serum lactate dehydrogenase (LDH), cardiac troponin, and myoglobin levels. Creatine kinase-MB serum levels decreased. Mancozeb only showed an increase in serum LDH. Both MZ and DS-treatment resulted in altered metal levels in the myocardium but not skeletal muscle. Ultrastructural alterations included damaged mitochondria and myofibril splitting. The presence of multivesicular bodies, and alterations of the intercalated disc were also seen.

二硫代氨基甲酸酯（DTC），如代森锰锌（MZ）和双硫仑（DS）在整个农业和医学中都被使用，并与神经毒性有关。关于由这些化合物引起的肌病的报道研究很少。它们的发病机理和肌肉毒性机理尚未得到充分研究。这项研究的目的是调查DTC是否在体内改变横纹肌组织。用MZ或DS治疗Long-Evans大鼠，然后分析肌肉生物标志物和金属水平。DS导致血清乳酸脱氢酶（LDH），心肌肌钙蛋白和肌红蛋白水平升高。肌酸激酶-MB血清水平降低。Mancozeb仅显示血清LDH升高。MZ和DS处理均导致心肌中金属含量的改变，但骨骼肌中的含量却没有改变。超微结构改变包括线粒体受损和肌原纤维分裂。还发现了多囊泡体的存在，以及插入的椎间盘的改变。