当前位置: X-MOL 学术BBA Biomembr. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Approach for comparing protein structures and origami models.
Biochimica et Biophysica Acta (BBA) - Biomembranes ( IF 3.4 ) Pub Date : 2019-11-15 , DOI: 10.1016/j.bbamem.2019.183132
Hay Azulay 1 , Aviv Lutaty 2 , Nir Qvit 3
Affiliation  

The research fields of proteins and origami have intersected in the study of folding and de-novo design of proteins. However, there is limited knowledge on the analogy between protein structures and origami models. We propose a general approach for comparing protein structures with origami models, and present a test case, comparing transmembrane β-barrel and α-helical barrel with the Yoshimura and Kresling origami models. While both shapes and structures may look similar, we demonstrated that the β-barrel and the α-helical barrel are in agreement only with the shape and structural characteristics of the Kresling model. Through the analogy, it is explained how the structural characteristic can help the β-barrel and α-helical barrel to adjust length and diameter in response to changes in the membrane structure. However, such conformations only apply to the α-helical barrel, and the β-barrel, in spite of resembles to the Kresling model, remains stiff due to hydrogen bonds between the β-strands. Thus, our analysis suggests that there are similar patterns between protein structures and origami models and that the proposed approach may provide important insight on the role that the structure of a protein fulfils, and on the preferred structural design of novel proteins with unique characteristics.

中文翻译:

比较蛋白质结构和折纸模型的方法。

蛋白质和折纸的研究领域与蛋白质折叠和新颖设计的研究相交。然而,关于蛋白质结构和折纸模型之间的类比的知识有限。我们提出了一种将蛋白质结构与折纸模型进行比较的通用方法,并提出了一个测试案例,将跨膜β桶和α螺旋桶与Yoshimura和Kresling折纸模型进行了比较。尽管形状和结构看起来都相似,但我们证明了β形桶和α形螺旋桶仅与Kresling模型的形状和结构特征一致。通过类推,解释了结构特征如何响应于膜结构的变化而帮助β-桶和α-螺旋桶调节长度和直径。然而,这种构象仅适用于α螺旋桶,尽管类似于Kresling模型,但β桶由于β链之间的氢键而保持刚性。因此,我们的分析表明,蛋白质结构和折纸模型之间存在相似的模式,并且所提出的方法可能提供重要的洞察力,以了解蛋白质实物结构的作用,以及具有独特特征的新型蛋白质的优选结构设计。
更新日期:2019-11-15
down
wechat
bug