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Monoterpenoid indole alkaloids from the fruits of Melodinus henryi
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2019-11-15 , DOI: 10.1016/j.phytol.2019.11.003
Qian Shao , Rui Ma , Xing Wu , Fa-Lei Zhang , Zheng-Hui Li , Tao Feng , Juan He , Ji-Kai Liu

Four undescribed monoterpenoid indole alkaloids, melodinines X1‒X4 (14), together with fourteen known ones, have been isolated from the fruits of Melodinus henryi. Their structures with absolute configurations were elucidated by extensive spectroscopic methods and ECD calculations. Compound 1 shows a significant cytotoxicity to HL-60 cancer cell line with an IC50 value of 0.8 μM.



中文翻译:

从果实的单萜吲哚生物碱山橙属果树

从melodinus henryi的果实中分离出四种未描述的单萜类吲哚生物碱,melodinines X 1 ‒ X 414)和十四种已知的单萜吲哚生物碱通过广泛的光谱学方法和ECD计算,阐明了它们具有绝对构型的结构。化合物1对HL-60癌细胞系显示出明显的细胞毒性,IC 50值为0.8μM。

更新日期:2019-11-15
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