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Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.
Trends in Immunology ( IF 16.8 ) Pub Date : 2019-11-16 , DOI: 10.1016/j.it.2019.10.008
Fei Zhong 1 , Shuang Liang 2 , Zhenyu Zhong 3
Affiliation  

Inflammation benefits the host by promoting the elimination of invading pathogens and clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and regeneration to restore homeostasis and organismal health. Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria. Here, we review the current understanding on the role of mtDNA in innate immunity, discussing how dysregulated mtDNA metabolism can promote chronic inflammation and disease progression.

中文翻译:

线粒体DNA作为炎症和疾病进展的主要驱动因素的新兴作用。

炎症通过促进组织损伤后入侵病原体的清除和细胞碎片的清除而有益于宿主。炎症还刺激组织修复和再生,以恢复体内平衡和机体健康。新兴证据表明,线粒体DNA(mtDNA)是真核细胞中非核DNA的唯一形式,当从压力线粒体中泄漏出来时,它是炎​​症的主要激活因子。在这里,我们回顾了对mtDNA在先天免疫中的作用的当前理解,讨论了mtDNA代谢失调如何促进慢性炎症和疾病进展。
更新日期:2019-11-17
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