当前位置: X-MOL 学术Chem. Nat. Compd. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A New Lignanamide Derivative and Bioactive Constituents of Lycium chinense
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2019-11-01 , DOI: 10.1007/s10600-019-02879-1
Hui-Chu Huang , Li-Chai Chen , Tsung-Hsien Chang , Tong-Fei Zhu , Chun-Lin Chen , Ming-Jen Cheng , Jih-Jung Chen

A new lignanamide derivative, lycichinenamide (1), has been isolated from the root barks of Lycium chinense together with nine known compounds, lyciumamide H (2), 5,2′-dihydroxy-6,7,8,6′-tetramethoxyflavone (3), 7α,8β-3′-O-methylcedrusin (4), smiglabrol (5), trans-N-caffeoyltyramine (6), vanillic acid (7), syringic acid (8), 2,6-dimethoxy-1,4-benzoquinone (9), and 1,5-dihydroxy-2-isoprenyl-3-methoxyxanthone (10). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, lycichinenamide (1), lyciumamide H (2), smiglabrol (5), and trans-N-caffeoyltyramine (6) showed potent inhibition with IC50 values of 18.5 ± 2.1, 21.8 ± 1.8, 12.4 ± 0.3, and 24.6 ± 2.0 μM, respectively, against LPS-induced NO generation. In addition, 1,5-dihydroxy-2-isoprenyl-3-methoxyxanthone (10) exhibited anti-Dengue virus activity with IC50 value of 22.4 ± 1.6 μM against Dengue virus serotype 2 strain PL046.

中文翻译:

枸杞的一种新的木酚酰胺衍生物和生物活性成分

从枸杞根皮中分离出一种新的木酚酰胺衍生物,即荔枝酰胺 (1),以及九种已知化合物:荔枝酰胺 H (2)、5,2'-二羟基-6,7,8,6'-四甲氧基黄酮 ( 3), 7α,8β-3'-O-methylcedrusin (4), smiglabrol (5), trans-N-caffeoyltyramine (6), vanillic acid (7), syringic acid (8), 2,6-dimethoxy-1 ,4-苯醌 (9) 和 1,5-二羟基-2-异戊二烯基-3-甲氧基氧杂蒽酮 (10)。通过光谱和质谱分析确定了新化合物 1 的结构。在分离株中,lycichinenamide (1)、lyciumamide H (2)、smiglabrol (5) 和 trans-N-caffeoyltyramine (6) 显示出有效的抑制作用,IC50 值为 18.5 ± 2.1、21.8 ± 1.8、12.4 ± 0.3 和 24 ± 2.0 μM,分别针对 LPS 诱导的 NO 生成。此外,1、
更新日期:2019-11-01
down
wechat
bug