Dual adhesiveness to tissue and implant biomaterials and bioactivity to stimulate tissue regeneration are interesting properties for developing new generations of tissue-repairing hydrogels with potential new clinical applications. In this study, we developed a unique bioglass (BG)/oxidized sodium alginate (OSA) composite hydrogel with adipic acid dihydrazide (ADH)-modified γ-polyglutamic acid (γ-PGA) as the cross-linking agent, in which the BG plays a multifunctional role to endow the hydrogel‍ with both dual-adhesive and bioactive properties. On one hand, the BG could improve the tissue-bonding strength by providing an alkaline microenvironment to stimulate the bond formation between OSA and the amino groups on the surrounding tissues. On the other hand, BG endows the hydrogel‍ with adhesiveness to implantable materials by releasing Ca ions, which might chelate with the carboxyl groups of the hydrogel‍ matrix. In addition, the composite hydrogel‍ showed excellent bioactivity to promote vascularization and accelerate tissue regeneration. This study demonstrates that a multifunctional hydrogel‍ can be designed by utilizing the multifunctional ions released from silicate BG, and the BG/OSA hydrogel shows good potential as an adhesive and bioactive material for wound-healing applications.

对组织和植入物生物材料的双重粘附以及刺激组织再生的生物活性是开发具有潜在新临床应用的新一代组织修复水凝胶的有趣特性。在这项研究中，我们开发了一种独特的生物玻璃（BG）/氧化海藻酸钠（OSA）复合水凝胶，其中己二酸二酰肼（ADH）改性的γ-聚谷氨酸（γ-PGA）作为交联剂，其中BG发挥多功能作用，赋予水凝胶双重粘合和生物活性。一方面，BG可通过提供碱性微环境来刺激OSA与周围组织上的氨基之间的键形成来提高组织结合强度。另一方面，BG通过释放Ca离子使水凝胶对可植入材料具有粘附性，可能与水凝胶基质的羧基螯合。此外，复合水凝胶具有出色的生物活性，可促进血管生成并促进组织再生。这项研究表明，可以利用从硅酸盐BG中释放的多功能离子来设计多功能水凝胶，而BG / OSA水凝胶作为伤口愈合应用中的粘合剂和生物活性材料显示出良好的潜力。