Engineering tissue-like scaffolds that can mimic the microstructure, architecture, topology, and mechanical properties of native tissues while offering an excellent environment for cellular growth has remained an unmet need. To address these challenges, multicompartment composite fibers are fabricated. These fibers can be assembled through textile processes to tailor tissue-level mechanical and electrical properties independent of cellular level components. Textile technologies also allow control of the distribution of different cell types and the microstructure of fabricated constructs and the direction of cellular growth within the 3D microenvironment. Here, we engineered composite fibers from biocompatible cores and biologically relevant hydrogel sheaths. The fibers are mechanically robust to being assembled using textile processes and could support adhesion, proliferation, and maturation of cell populations important for the engineering of skeletal muscles. We also demonstrated that the changes in the coating of the multicompartment fibers could potentially enhance myogenesis in vitro.

中文翻译：

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用于工程骨骼肌模型的可定制复合纤维

工程组织类支架能够模仿天然组织的微观结构、结构、拓扑和机械性能，同时为细胞生长提供良好的环境，但这一需求仍然未得到满足。为了应对这些挑战，制造了多室复合纤维。这些纤维可以通过纺织工艺组装，以定制独立于细胞级成分的组织级机械和电性能。纺织技术还可以控制不同细胞类型的分布、制造结构的微观结构以及 3D 微环境中细胞生长的方向。在这里，我们用生物相容性芯和生物相关的水凝胶鞘设计了复合纤维。这些纤维具有机械强度，适合使用纺织工艺组装，并且可以支持对骨骼肌工程重要的细胞群的粘附、增殖和成熟。我们还证明，多室纤维涂层的变化可能会增强肌生成体外。